DR STEPHANIE SENEFF

Senior Research Scientist MIT Computer Science and Artificial Intelligence Laboratory

Dr. Stephanie Seneff is a Senior Research Scientist at MIT. She has a BS degree from MIT in biology and a PhD from MIT in electrical engineering and computer science. She has published over 200 peer-reviewed papers in scientific journals and conference proceedings. Her recent interests have focused on the role of toxic chemicals and micronutrient deficiencies in health and disease, with a special emphasis on the pervasive herbicide, Roundup, and the mineral, sulfur. She has authored over two dozen peerreviewed journal papers over the past few years on these topics, and has delivered numerous slide presentations around the world.

Dr Stephanie Seneff: Glyphosate disruption of methylation/ transsulfuration pathways as a key factor in chronic diseases.

Glyphosate is the active ingredient in the pervasive herbicide, roundup and is a common contaminant in our food supply. It is not adequately monitored due to its perceived minimal toxicity to humans. Stephanie has identified a link between glyphosate and a large number of metabolic disorders, one of which is impairment in the methylation and transsulfuration pathways.

Glyphosate has been shown to deplete methionine supplies in plants, and to suppress certain enzymes in common gut microbes that incorporate sulfur from sulfite and sulfate. Glyphosate also plausibly disrupts the pathway that supplies methyl groups from glycine. Furthermore, glyphosate can be expected to disrupt the supply of the essential B vitamin, folate, since it is derived from the shikimate pathway which glyphosate suppresses. An awareness of a link between folate deficiency and spina bifida has led to regulatory action in the United States and Australia to require folic acid fortification in wheat-based products. This has not actually solved the problem of folate deficiency, and may in fact make things worse, particularly with regard to increasing risk to autism. In addition, multiple mechanisms by which glyphosate disrupts the supply of sulfate to the body lead to an epidemic in sulfate deficiency in our population, which is linked to a long list of debilitating diseases.