October 27, 2025

What vitamin B6’s active form (PLP) reveals about enzyme fidelity, neurological resilience, and why ‘more B6’ isn’t always the right answer. The B Vitamin We Thought We Understood Ask any clinician to name the functions of vitamin B6, and you’ll hear the usual suspects: amino acid metabolism, neurotransmitter synthesis, perhaps a nod to its role […]

Kidney stones aren’t just a dietary issue—they’re a microbial one. Here’s how the absence of one bacterial species could reshape how we think about nephrolithiasis. What We Miss When We Only Focus on Oxalate Intake Calcium oxalate stones are the most common type of kidney stone—and if you’ve had one, the recurrence risk is high.

If you think methylation is just about MTHFR and folate, think again. There’s a rare disease that forces us to reckon with the very fundamentals of sulfur metabolism—and it teaches us more than you’d expect about the broader landscape of chronic disease, longevity, and metabolic resilience. Let’s talk about homocystinuria. It’s rare—so rare that most

What if a standard multivitamin could quietly damage your nerves over time? This isn’t a hypothetical — it’s a clinical pattern showing up with surprising regularity. And for years, we’ve largely misunderstood why. Vitamin B6, often taken in the form of pyridoxine, is essential for over 100 enzymatic reactions. It helps synthesize neurotransmitters, regulate methylation,