What Is Blood Clotting?
Some people are born with an increased tendency to form blood clots, which increases their risk for developing blood clots in the legs (deep vein thrombosis) and in the lungs (pulmonary embolism).
The medical term for a blood clot is a thrombus (plural= thrombi). When a thrombus is formed as part of a normal repair process of the body, there is little consequence. Unfortunately, there are times when a thrombus (blood clot) will form when it is not needed, and this can have potentially significant consequences.
Research
1. MTHFR A1298C + C677T Associated with Blood Clotting
The true cause of blood clotting of the retina’s vein was examined in this study be Mrad et al (2014). Results showed the A1298C polymorphism to be significantly associated with clotting of the retinal vein. The C677T gene was found to be significantly higher among these patients.
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2. MTHFR C677T, High Homocysteine + Blood Clot Risk
The relationship between homocysteine (Hcy), MTHFR C677T polymorphism and cerebral (brain) blood clot risk was studied by Bharatkumar et al (2014). Homocysteine was higher in patients with cerebral blood clotting, representing a 4.54 fold increased risk of brain blood clotting. When examining the link with MTHFR C677T, the authors concluded that the 677TT genotype was not linked with blood clot risk, but is a determinate of homocysteine levels.
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