Tito

The Importance of the Folate Pathway: How Methylfolate Impacts Overall Health

The folate pathway is one of the body’s most essential processes, affecting everything from cellular repair to neurotransmitter production. Central to this pathway is methylfolate, the active form of folate that drives many crucial functions within the body. However, when there are disruptions in methylfolate production—often due to genetic variations—our health can be profoundly impacted. […]

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What Makes Smart DNA Different from 23andMe and AncestryDNA? A Clinician’s Tool for Personalised Health

What Makes Smart DNA Different from 23andMe and AncestryDNA? A Clinician’s Tool for Personalised Health Genetic testing has become increasingly popular, with consumer-oriented companies like 23andMe and AncestryDNA leading the way in ancestry and general health insights. But for practitioners who want deeper, actionable insights into their patients’ health, Smart DNA offers a targeted, clinically-focused

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Why Genomic Testing is a Game-Changer in Clinical Practice: Improving Patient Outcomes Through Precision Health

In recent years, healthcare has moved towards more personalised approaches, with genomic testing emerging as a powerful tool to tailor treatments to each individual. Unlike traditional methods that often rely on standardised treatment protocols, genomic testing provides insights into a patient’s unique genetic blueprint. For clinicians, this means a deeper understanding of a patient’s vulnerabilities

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Exploring Genetic Susceptibility and the Role of FUT2 in Disease Risk

Genetic predispositions play a crucial role in shaping health outcomes, and one particular gene, FUT2 (fucosyltransferase 2), has gained attention for its wide-ranging implications. From autoimmune diseases to gut health and metabolic conditions, understanding FUT2 and its impact on health can provide deeper insights into disease susceptibility and targeted interventions. FUT2 and Secretor Status: An

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Understanding Akkermansia: The Gut Microbe You Should Know About

When discussing gut health and its crucial role in overall well-being, certain bacteria often take center stage. However, one lesser-known but highly significant player is Akkermansia muciniphila. This microorganism, now gaining more attention among gut health specialists, holds potential in managing and even preventing certain health conditions. Here, we delve into what Akkermansia is, its

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MTHFR in Gastroenterology and Diabetology: Connecting Homocysteine, Genetics, and Metabolic Disease

Introduction Type 2 diabetes mellitus (T2DM), gestational diabetes, metabolic syndrome, obesity, fatty liver disease, and inflammatory bowel disease may seem like distinct clinical entities. But beneath their varied presentations lies a biochemical thread that connects them: homocysteine metabolism. The methylenetetrahydrofolate reductase (MTHFR) enzyme—often discussed in relation to cardiovascular or neurological disease—also plays a surprisingly important

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When B-Vitamins Are Life-Saving: The Forgotten Diagnoses Behind Stroke, Dementia, and Psychiatric Decline

CBS and MTHFR deficiencies aren’t just rare childhood disorders—they may be hiding behind your adult patient’s “idiopathic” neurological symptoms. We often associate inborn errors of metabolism with paediatrics: neonates in NICUs, metabolic crises, urgent interventions. But what happens when these genetic disorders masquerade as psychiatric illness, unexplained strokes, or progressive dementia in adults? A 2007

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MTHFR and the Brain: Untangling the Genetic and Biochemical Links to Neurological and Psychiatric Disorders

When we talk about MTHFR polymorphisms, most practitioners think about methylation, cardiovascular risk, or pregnancy complications. But increasingly, the research is pointing to a different arena where these gene variants may play a pivotal role: the brain. From autism spectrum disorder to schizophrenia and major depression, MTHFR-related impairments in one-carbon metabolism may alter neurodevelopment, neurotransmission,

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Choline – The Unsung Hero of Methylation

Methylation is a fundamental biochemical process that underpins everything from gene regulation and detoxification to neurotransmitter production and liver health. Most health practitioners are familiar with folate’s role in methylation—particularly in relation to homocysteine metabolism and MTHFR polymorphisms—but what’s less appreciated is the equally essential role of choline. Emerging research, including a 2025 review by

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gut bug

How Gut Bugs and Inflammation Steal Your Tryptophan (and Your Happiness)

You’ve heard the phrase “the gut-brain axis.” But in clinical practice, that connection runs deeper than many practitioners realise—especially when it comes to tryptophan metabolism and its downstream impact on serotonin, mood, and inflammation. Today’s article dives into the mechanism of tryptophan hijacking—how gut bugs, inflammation, and environmental stress redirect this essential amino acid away

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Carolyn Ledowsky

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